Genetic Variants Concomitantly Influence Nonalcoholic Fatty Liver Disease and Metabolic Traits

Genetic Variants Concomitantly Influence Nonalcoholic Fatty Liver Disease and Metabolic Traits

Overview

Nonalcoholic fatty liver disease  NAFLD) is associated with metabolic disorders,  such as:

 

  • overall (body mass index BMI) and central obesity (waist circumference   WAIST) and visceral abdominal adipose tissue   VAT))
  • dyslipidemia (high levels of triglycerides TG) and low levels of high-density lipoprotein cholesterol HDL))
  • impaired glucose tolerance (high fasting levels of glucose GLU) and insulin    NS))

 

Several variants were discovered by genome- wide association (GWA) studies fo  NAFLD and for these correlated disorders

 

But, few efforts have focused on determining whether the discovered genes/loci influence concomitantly these traits

 

Objective

 

To identify common variants contributing to pleiotropic effects NAFLD (using CT measured fatty live  ) and metabolic traits, performing  correlated meta-analysis approach.