Genetic Variants Concomitantly Influence Nonalcoholic Fatty Liver Disease and Metabolic Traits
Nonalcoholic fatty liver disease NAFLD) is associated with metabolic disorders, such as:
- overall (body mass index BMI) and central obesity (waist circumference WAIST) and visceral abdominal adipose tissue VAT))
- dyslipidemia (high levels of triglycerides TG) and low levels of high-density lipoprotein cholesterol HDL))
- impaired glucose tolerance (high fasting levels of glucose GLU) and insulin NS))
Several variants were discovered by genome- wide association (GWA) studies fo NAFLD and for these correlated disorders
But, few efforts have focused on determining whether the discovered genes/loci influence concomitantly these traits
To identify common variants contributing to pleiotropic effects NAFLD (using CT measured fatty live ) and metabolic traits, performing correlated meta-analysis approach.