Saccone Lab

Overview: Our lab uses mathematical and statistical methods to understand human genetic variation and its contribution to complex diseases and traits. Research areas include the impact of linkage disequilibrium (LD) and haplotype structure on the design and interpretation of genetic mapping studies, extending genetic research to include understudied populations, and increasing power to detect genetic loci, e.g. through collaborative meta-analyses. Applied projects focus on addiction, psychiatric diseases, and other complex traits.

About the Study:
This research study is being conducted by investigators at Washington University in Saint Louis, Missouri and is funded by the National Institutes of Health. The overall goal is to understand factors that affect cannabis use and medically relevant effects of cannabis use, such as pain relief and cannabis-related paranoia.

More information on this study will be posted soon.

Doctoral Students:

Shelina Ramnarine
Ph.D. in Human and Statistical Genetics 2016
Doctoral Thesis: Genetic Imputation: From Accuracy to Application

Tae-Hwi Linus Schwantes-An
Ph.D. in Human and Statistical Genetics 2013
Doctoral Thesis: Enhancing Biological Insights Through Statistical Inferences

Peter Liu
M.S. in Genetic Epidemiology 2005
Ph.D. in Human and Statistical Genetics 2011
Doctoral Thesis: Identification of Genetic/Epigenetic Risk Factors for Psoriasis and Psoriatic Arthritis
(co-mentor with Dr. Anne Bowcock)


Masters Students:

Juan Zhang
M.S. in Genetic Epidemiology 2010
Masters Thesis: Genetic Variation, Population Structure, and Risk for Nicotine Dependence in African-Americans and European-Americans

Peter Nagele, M.D.
M.S. in Genetic Epidemiology 2010
Masters Thesis: Genetic and Environmental Determinants of Total Homocysteine: Impact of Population-Wide Folate Fortification
(co-mentor with Dr. Anne Bowcock)

Hsien-Ning Liu
M.S. in Genetic Epidemiology 2009
Masters Thesis: Analysis of Genotyped and Imputed Variants in the Nicotinic Receptor Subunit Genes Outside CHRNA5-CHRNA3-CHRNB4 for Association with Nicotine Dependence

Andrew J. Schrage
M.S. in Genetic Epidemiology 2008
Masters Thesis: Combining Imputation and Cross-population Analysis to Refine and Localize a Cocaine Dependence Association Signal on Chromosome 15

Saccone NL, Emery LS, Sofer T, Gogarten SM, Becker DM, Bottinger EP, Chen L-S, Culverhouse RC, Duan W, Hancock DB, Hosgood HD, Johnson EO, Loos RJF, Louie T, Papanicolaou G, Perreira KM, Rodriquez EJ, Schurmann C, Stilp AM, Szpiro AA, Talavera GA, Taylor KD, Thrasher JF, Yanek LR, Laurie CC, Pérez-Stable EJ, Bierut LJ, Kaplan RC (2018). Genome-wide association study of heavy smoking and daily/nondaily smoking in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL). Nicotine and Tobacco Research 20:448-457. PMCID: PMC5896462.

Culverhouse RC, Saccone NL, Horton AC, Ma Y, Anstey KJ, Banaschewski T, Burmeister M, Cohen-Woods S, Etain B, Fisher HL, Goldman N, Guillaume S, Horwood J, Juhasz G, Lester KJ, Mandelli L, Middeldorp CM, Olié E, Villafuerte S, Air TM, Araya R, Bowes L, Burns R, Byrne EM, Coffey C, Coventry WL, Gawronski KA, Glei D, Hatzimanolis A, Hottenga JJ, Jaussent I, Jawahar C, Jennen-Steinmetz C, Kramer JR, Lajnef M, Little K, Zu Schwabedissen HM, Nauck M, Nederhof E, Petschner P, Peyrot WJ, Schwahn C, Sinnamon G, Stacey D, Tian Y, Toben C, Van der Auwera S, Wainwright N, Wang JC, Willemsen G, Anderson IM, Arolt V, Åslund C, Bagdy G, Baune BT, Bellivier F, Boomsma DI, Courtet P, Dannlowski U, de Geus EJ, Deakin JF, Easteal S, Eley T, Fergusson DM, Goate AM, Gonda X, Grabe HJ, Holzman C, Johnson EO, Kennedy M, Laucht M, Martin NG, Munafò MR, Nilsson KW, Oldehinkel AJ, Olsson CA, Ormel J, Otte C, Patton GC, Penninx BW, Ritchie K, Sarchiapone M, Scheid JM, Serretti A, Smit JH, Stefanis NC, Surtees PG, Völzke H, Weinstein M, Whooley M, Nurnberger JI Jr, Breslau N, Bierut LJ (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry 23:133-142.

Saccone NL, Baurley JW, Bergen AW, David SP, Elliott HR, Foreman MG, Kaprio J, Piasecki TM, Relton CL, Zawertailo L, Bierut LJ, Tyndale RF, Chen L-S on behalf of the Genetics and Treatment Networks of the Society for Research on Nicotine and Tobacco (SRNT) (2018). The value of biosamples in smoking cessation trials: A review of genetic, metabolomic, and epigenetic findings. Nicotine and Tobacco Research 20: 403-413.

Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Müller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nöthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerström N, Scherbaum N, Schmäl C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafò MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL (2016). Association of the OPRM1 variant rs1799971 (A118G) with non-specific liability to substance dependence in a collaborative de novo meta-analysis of European-ancestry cohorts. Behav Genet 46:151-169. PMCID: PMC4752855.

Ramnarine S, Zhang J, Chen LS, Culverhouse R, Duan W, Hancock DB, Hartz SM, Johnson EO, Olfson E, Schwantes-An TH, Saccone NL (2015). When Does Choice of Accuracy Measure Alter Imputation Accuracy Assessments? PLoS One 10(10):e0137601. PMCID: PMC4601794.

Schwantes-An T-H, Culverhouse RC, Duan W, Ramnarine S, Rice JP, Saccone NL (2013). Interpreting joint SNP analysis results: when are two distinct signals really two distinct signals? Genet Epidemiol 2013: 37:301-309. PMCID: PMC3743534.

List of publications in PubMed: