Aldi T Kraja

Aldi T Kraja

aldi@wustl.edu

Website

https://dsgwebwp.wustl.edu/dsgweb_userprofiles/aldi/

https://dsgwebwp.wustl.edu/mtdna/pleionet/chargemtdna

Current Position

Research Associate Professor of Genetics

 

Education

Year University Degree, Major
1993 Agriculture University, Tirana, Albania DSc, Quantitative Genetics
1999 University of Illinois, Urbana-Champaign, USA PhD, Quantitative Genetics

 

Teaching

Years Course University
1981-1993 Genetics (Lecturer) Agriculture University, Tirana, Albania
1995-1998 Statistics (TA) University of Illinois, Urbana, IL, USA
2000-2005 SAS Programming (Lecturer) Washington University,

St. Louis, MO, USA

2008-2014 Computational Genetics (Co-Lecturer) Washington University,

St. Louis, MO, USA

 

Research Interests

  • Metabolic syndrome, obesity, dyslipidemia, insulin resistance, hypertension and inflammatory markers
  • Genetic epidemiology, quantitative genetics and bioinformatics
  • Multivariate analysis, simulations, data mining / machine learning
  • Personalized medicine by predicting disease via informative genetic and phenotypic biomarkers

 

Representative Publications

1: Liu C, Kraja AT, Smith JA, Brody JA, Franceschini N, Bis JC, Rice K, Morrison AC, Lu Y, Weiss S, Guo X, Palmas W, Martin LW, Chen YD, Surendran P, Drenos F, Cook JP, Auer PL, Chu AY, Giri A, Zhao W, Jakobsdottir J, Lin LA, Stafford JM, Amin N, Mei H, Yao J, Voorman A; CHD Exome+ Consortium.; ExomeBP Consortium. ;GoT2DGenes Consortium.; T2D-GENES Consortium., Larson MG, Grove ML, Smith AV, Hwang SJ, Chen H, Huan T, Kosova G, Stitziel NO, Kathiresan S, Samani N, Schunkert H, Deloukas P; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia., Li M, Fuchsberger C, Pattaro C, Gorski M; CKDGen Consortium., Kooperberg C, Papanicolaou GJ, Rossouw JE, Faul JD, Kardia SL, Bouchard C, Raffel LJ, Uitterlinden AG, Franco OH, Vasan RS, O’Donnell CJ, Taylor KD, Liu K, Bottinger EP, Gottesman O, Daw EW, Giulianini F, Ganesh S, Salfati E, Harris TB, Launer LJ, Dörr M, Felix SB, Rettig R, Völzke H, Kim E, Lee WJ, Lee IT, Sheu WH, Tsosie KS, Edwards DR, Liu Y, Correa A, Weir DR, Völker U, Ridker PM, Boerwinkle E, Gudnason V, Reiner AP, van Duijn CM, Borecki IB, Edwards TL, Chakravarti A, Rotter JI, Psaty BM, Loos RJ, Fornage M, Ehret GB, Newton-Cheh C, Levy D, Chasman DI. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016 Oct;48(10):1162-70. doi: 10.1038/ng.3660. PubMed PMID: 27618448.

2:  Aldi T. Kraja, Daniel I. Chasman, Kari E. North, Alexander P. Reiner, Lisa R. Yanek, Tuomas O. Kilpeläinen, Jennifer A. Smith, Abbas Dehghan, Josée Dupuis, Andrew D. Johnson, Mary F. Feitosa, Fasil Tekola-Ayele, Audrey Y. Chu, Ilja M. Nolte, Zari Dastani, Andrew Morris, Sarah A. Pendergrass, Yan V. Sun, Marylyn D. Ritchie, Ahmad Vaez, Honghuang Lin, Symen Ligthart, Letizia Marullo, Rebecca Rohde, Yaming Shao, Mark A. Ziegler, Hae Kyung Im, Cross Consortia Pleiotropy (XC-Pleiotropy) Group, the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE), the Genetic Investigation of Anthropometric Traits (GIANT) Consortium, the Global Lipids Genetics Consortium (GLGC), the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), the Global BPgen (GBPG) Consortium, The ADIPOGen Consortium, the Women’s Genome Health Study (WGHS), the Howard University Family Study (HUFS), Renate B. Schnabel, Torben Jørgensen, Marit E. Jørgensen, Torben Hansen, Oluf Pedersen, Ronald P. Stolk, Harold Snieder, Albert Hofman, Andre G. Uitterlinden, Oscar H. Franco, M. Arfan Ikram, J. Brent Richards, Charles Rotimi, James G. Wilson, Leslie Lange, Santhi K. Ganesh, Mike Nalls, Laura J. Rasmussen-Torvik, James S. Pankow, Josef Coresh, Weihong Tang, W.H. Linda Kao, Eric Boerwinkle, Alanna C. Morrison, Paul M. Ridker, Diane M. Becker, Jerome I. Rotter, Sharon L.R. Kardia, Ruth J.F. Loos, Martin G. Larson, Yi-Hsiang Hsu, Michael A. Province, Russell Tracy, Benjamin F. Voight, Dhananjay Vaidya, Christopher J. O’Donnell, Emelia J. Benjamin, Behrooz Z. Alizadeh, Inga Prokopenko, James B. Meigs, Ingrid B. Borecki. Pleiotropic genes for metabolic syndrome and inflammation. Molecular Genetics and Metabolism. 2014

3: Kraja AT, Borecki IB, Tsai MY, Ordovas JM, Hopkins PN, Lai CQ, Frazier-Wood AC, Straka RJ, Hixson JE, Province MA, Arnett DK. Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study. Lipids. 2013Feb;48(2):155-65. PMID: 23192668.

4: Kraja AT, Lawson HA, Arnett DK, Borecki IB, Broeckel U, de las Fuentes L, Hunt SC, Province MA, Cheverud J, Rao DC. Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice. Metabolism. 2012 Aug;61(8):1129-41. PMID: 22386932.

5: Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, Sovio U, Mathias RA, Sun YV, Franceschini N, Absher D, Li G, Zhang Q, Feitosa MF, Glazer NL, Haritunians T, Hartikainen AL, Knowles JW, North KE, Iribarren C, Kral B, Yanek L, O’Reilly PF, McCarthy MI, Jaquish C, Couper DJ, Chakravarti A, Psaty BM, Becker LC, Province MA, Boerwinkle E, Quertermous T, Palotie L, Jarvelin MR, Becker DM, Kardia SL, Rotter JI, Chen YD, Borecki IB. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes. 2011Apr;60(4):1329-39. PMID: 21386085.